Product Name :
cGAS Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
C6orf150 antibody cGAMP synthase antibody cGAS antibody CGAS_HUMAN antibody cGMP Synthase antibody Chromosome 6 open reading frame 150 antibody Cyclic GMP-AMP synthase antibody h-cGAS antibody Hypothetical protein LOC115004 antibody Mab 21 domain containing 1 antibody 展开
Function :
cGAS Antibody (C-1) is a high quality monoclonal cGAS antibody (also designated cGAS antibody) suitable for the detection of the cGAS protein of human origin. cGAS Antibody (C-1) is available as the non-conjugated anti-cGAS antibody. The presence of foreign DNA in the cytoplasm induces an antiviral host immune response. DNA in the cytoplasm triggers the production of interferons by activating and synthesis of second messenger cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP). cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.Price of Ethyl 2-amino-1H-imidazole-5-carboxylate
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within C-terminal human cGAS.BuyFmoc-L-Lys(ivDde)-OH
Species reactivity:
Human, Mouse, Rat, Pig
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
AB_3071123
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33631296 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 59 kDa
Positive control :
MCF-7 cell lysate, THP-1 cell lysate, Hela cell lysate, rat lung tissue lysate, A431, LOVO, SKOV-3, L-929, human colon carcinoma tissue, human uterus tissue, mouse kidney tissue, rat bladder tissue.