Product Name :
2-(Trimethylsilyl)ethoxymethyl chloride (CAS 76513-69-4)

Synonym :
(2-Chloromethoxyethyl)trimethylsilane; Chloromethyl 2-trimethylsilylethyl ether; SEM-chloride; SEM-Cl

Application :

CAS:
76513-69-4

Purity:

Molecular Weight:
166.72

Formula :
C6H15ClOSi

Physical state:
Liquid

solubility :
Soluble in water (decomposes).

Shipping Condition :
Store at 4° C

Melting point:

SMILES:
C[Si](C)(C)CCOCCl

References:
:AMP deaminase inhibitors.Buy4-Bromo-5-methyl-1H-indazole 2. Initial discovery of a non-nucleotide transition-state inhibitor series. | Bookser, BC., et al. 2000. J Med Chem. 43: 1495-507. PMID: 10780906The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. | Takahashi, K., et al. 2009. Bioorg Med Chem. 17: 7042-51. PMID: 19736020Terminating Catalytic Asymmetric Heck Cyclizations by Stereoselective Intramolecular Capture of eta -Allylpalladium Intermediates: Total Synthesis of (−)-Spirotryprostatin B and Three Stereoisomers. | Overman, LE. and Rosen, MD. 2010. Tetrahedron. 66: 6514-6525. PMID: 20725641Synthesis and evaluation of C-ring aromatized analogues of phenanthridone alkaloids. | Lee, S., et al. 2011. Arch Pharm Res. 34: 1065-70. PMID: 21811912Synthesis of [3-N-(11) C-methyl]temozolomide via in situ activation of 3-N-hydroxymethyl temozolomide and alkylation with [(11) C]methyl iodide. | Eriksson, J., et al. 2015. J Labelled Comp Radiopharm. 58: 122-6. PMID: 25693064Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.2-Methoxybenzenesulfonyl chloride supplier | Wang, Q., et al. 2018. J Med Chem. 61: 7877-7891. PMID: 30122035Baricitinib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Janus Kinases. | Mayence, A. and Vanden Eynde, JJ. 2019. Pharmaceuticals (Basel). 12: PMID: 30871014Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. | Wang, P., et al. 2019. ACS Med Chem Lett. 10: 792-799. PMID: 3109800118F-Labelled pyrrolopyrimidines reveal brain leucine-rich repeat kinase 2 expression implicated in Parkinson′s disease.PMID:33590992 | Chen, X., et al. 2021. Eur J Med Chem. 214: 113245. PMID: 33582389Synthesis and duplex-forming ability of oligonucleotides modified with 4′-C,5′-C-methylene-bridged nucleic acid (4′,5′-BNA). | Yamaguchi, T., et al. 2021. Bioorg Med Chem. 46: 116359. PMID: 34391942Synthesis, antiviral and antitumor activities investigations of a series of Ribavirin C-nucleoside analogue prodrugs. | Sabat, N., et al. 2022. Bioorg Chem. 122: 105723. PMID: 35278778A novel photocaged B-RafV600E inhibitor toward precise melanoma treatment. | Chen, Z., et al. 2022. Bioorg Med Chem Lett. 64: 128683. PMID: 35307569Regioselective protection of the 2′-hydroxyl group of N-acyl-3′, 5′-O-di (t-butyl) silanediylnucleoside derivatives by use of t-BuMgCl and 2-(trimethylsilyl) ethoxymethyl chloride | Wada, T., Tobe, M., Nagayama, T., Furusawa, K., & Sekine, M. 1995. Tetrahedron letters. 36(10): 1683-1684.